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Does anyone here on Tacro use CBD oil to alleviate other issues? Everything I've read about CBD oil online makes it sound very benign, but my transplant pharmacist found a study showing that CBD inhibits a liver enzyme needed to metabolize Tacro, meaning it could have a similar effect to grapefruit in terms of increasing drug concentrations in the blood, possibly to toxic levels. This was a study done in rats, not humans, and there are no anecdotal cases to my knowledge of anyone having Tacro toxicity due to CBD. Does anyone have any info on this? Thanks. 

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  • As to the question about providing a link......this is not the case study that was mentioned but interesting since from a site that sells CBD.

    The data from specific research is hard to come by.  Again, no impact on my nerve pain but our bodies metabolize differently and mine does not recognize it.  

    But here is some information - take it as you will and further research it.  I did just because that is what I used to do for a living so it is interesting and confusing the deeper you get.  We are not there anytime soon but eventually they will have better understanding of strains and how they impact differently for different people.  I can't take ibuprofin due to my medical situation but Tylenol and Aleve and the rest do not work, for me.  Just how strains may be someday.

    https://cbdoilreview.org/cbd-cannabidiol/cbd-p-450-enzyme/

    Drugs that May Interact with CBD Oil
    Some of CBD's side effects can be dangerous if you do not understand the Cytochrome P-450 System. Discover which drugs are dangerous to combine with…
    • Jeff, I see you posted here a year ago that you tried CBD and didn't find it that helpful. I'm wondering how long you tried it? Did it ever increase your tacro levels? Thank you

      Drugs that May Interact with CBD Oil
      Some of CBD's side effects can be dangerous if you do not understand the Cytochrome P-450 System. Discover which drugs are dangerous to combine with…
      • I tried it for a number of months off/on.  I went off for 6 weeks to clear my system as I was also being looked at for a Heart TX.  

        I have to admit my pain is chronic nerve pain - mostly post Shingles which I got in 2016 after my TX team added Myfortic fpr "safety".  3 weeks later Shingles and my pain never left.  I was not told it impacted my Tacro levels as they have been pretty regulated.

        Unrelated, but I would remind all to really make sure you hit the 11.5 Hour mark with your Tacro blood tests.  It is not always mentioned but I keep within 30 minutes of that time by taking night meds based on when I can give blood.  But I cannot speak to level changes. CBD/THC or the like need to be eaten since we cannot smoke anything.  You will find in research how different it may be with where something you eat is metabolized vs something inhaled.

        Last - when I did try either I really only noticed a bit of a body buzz but with all my meds I can/could not regulate when it "kicked in".  2-8 hours sometimes for me. 

        Drugs that May Interact with CBD Oil
        Some of CBD's side effects can be dangerous if you do not understand the Cytochrome P-450 System. Discover which drugs are dangerous to combine with…
  • Hi Hilary, How are you?

    Do you have any updates? How is the cbd oil use? And which brand do you use?

    I purchased CBD Pure, going to try. Have you tried this brand before? I am looking for an organic, non-gmo, pure clean cbd oil. Thought to consult w. you. Thank you.

    • Hi, I didn't end up trying it. There is a case report of someone's Prograf level becoming dangerously high because of CBD, and the liver enzyme it inhibits is involved in the metabolism of many different drugs it turns out. I'd love to try it but it doesn't seem safe. 

      • Could you please share links Hilary?

        • Also if you do try it and want to share your results, I'd appreciate it! 

          • I am still checking, but will share any info I have. For sure.

            Those links you and Brad shared are very useful. Thank you again, Hillary.

        • I would imagine there are plenty of transplant patients who assume it's safe and do so without repercussion but I have no idea. I asked my nephrologist if I could start at a very low dose and they could just monitor my tacro level but they didn't seem amenable to the idea. I might try it anyway, if not cbd then medical marijuana, because I need something for chronic pain and it seems insane and cruel that the only thing they can offer me is Tylenol. 

        • Here is one link to a case study about someone who ate edibles, more significant is the link Jeff Cutler just posted in the comments section here. I also talked with my nephrologist about this and he referred me to the transplant pharmacist at Tufts; he was the one to tell me it's not safe. My sister also works at a dispensary and they're aware of the interaction with drugs that require this enzyme for metabolism. https://www.hindawi.com/journals/crit/2016/4028492/

          High on Cannabis and Calcineurin Inhibitors: A Word of Warning in an Era of Legalized Marijuana
          Tacrolimus, a potent immunosuppressant medication, acts by inhibiting calcineurin, which eventually leads to inhibition of T-cell activation. The dru…
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