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Does anyone here on Tacro use CBD oil to alleviate other issues? Everything I've read about CBD oil online makes it sound very benign, but my transplant pharmacist found a study showing that CBD inhibits a liver enzyme needed to metabolize Tacro, meaning it could have a similar effect to grapefruit in terms of increasing drug concentrations in the blood, possibly to toxic levels. This was a study done in rats, not humans, and there are no anecdotal cases to my knowledge of anyone having Tacro toxicity due to CBD. Does anyone have any info on this? Thanks. 

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  • Here's the study that I think your guy was referencing:

    I've been taking CBD in a modest amount for about 3 months and started it to alleviate anxiety which it has done. As a liver recipient however I was watching the tacro levels. The above study and the comments below indicate that CBD may inhibit the metabolikzation of tacro which I find to be possibly a positive discovery.  I understand that tacro and the other reated immuno-suppresants are toxic to the kidneys; If cbd slows down but does not prevent the metabolization of tacro then, presumably, a patient would need to reduce their dose. Provided the patient had no indications of rejection then wouldn't this reduce the toxic effects of the tacro? 

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  • My team here in Houston does not reccommend me taking this or any other over the counter herbal medication without them going over it first and CBD is not on the approval list....


  • I have been on tacro for 3 1/2 yrs with the no issues with my levels until 5 weeks ago when I decided to try CBD to help with my chronic pain. I started taking 9mg CBD gummies 3 times a day so approximately 27 mgs of CBD daily for about 2 weeks. My first lab results after starting CBD were alarming as my tacro level more than doubled! It had been consistently 7 and now it was 17. I was taking 2 & 1/2 in the morning & 2 at night. They started lowering my tacro by 5 & rechecking labs weekly. Two days ago was the 3rd time my labs were rechecked in as many weeks & my tacro is still too high. It was 10. I have not taken any CBD at all in 3 weeks but I was told it can stay in your system for a while. So now I'm down to 1 & 1/2 in the am & 1 & 1/2 in the pm. Getting labs redone next Monday. The ONLY thing I had done differently was take CBD so they are pretty certain that, that is the cause of my tacro issues. I have done research as well and it definitely can interfere with tacro absorption . Be careful people! I am disappointed since the CBD truly helped with my pain issues. 

    • You may have just saved my life.

      I just purchased and received CDB Pure in the mail because I’m looking for an alternative to oxycodone and I just started getting severe lower right-side back, thigh and knee pain, which doctor says is hip arthritis. I never had this problem before, but pain is devastating.  So I got CBD but waited a couple of days. For reasons unknown I signed onto transplant friends, which I haven’t done in months and your notice came. I was just going to take it too. Thank you, thank you.  


    • Wow, the timing of your comment is strange. I just got out of the hospital after being admitted for tacro toxicity (my level was 16, my target range is 3). We don't know what caused it because I haven't tried anything new- except- a few weeks ago- I was given a bottle of pain relief lotion from a medical dispensary that has CBD in it. I only used it maybe four times on my shoulders and neck (and it did work well!) but then I stopped because I was worried about the CBD interaction. I figured because that was weeks ago and I only used it a few times that couldn't be the cause of the toxicity- I was also told that because I wasn't directly ingesting it it wouldn't get into my blood stream- maybe I should reconsider though? I didn't tell the doctors about it because I didn't think that could be it. Not going to use it again as the toxicity has been a nightmare. I hope you're feeling okay and that your levels come down. I had diarrhea and severe nausea and electrolye imbalance, elevated liver enzymes, all the symptoms. It was scary and I still don't feel right even though the level has come down. 

  • As to the question about providing a link......this is not the case study that was mentioned but interesting since from a site that sells CBD.

    The data from specific research is hard to come by.  Again, no impact on my nerve pain but our bodies metabolize differently and mine does not recognize it.  

    But here is some information - take it as you will and further research it.  I did just because that is what I used to do for a living so it is interesting and confusing the deeper you get.  We are not there anytime soon but eventually they will have better understanding of strains and how they impact differently for different people.  I can't take ibuprofin due to my medical situation but Tylenol and Aleve and the rest do not work, for me.  Just how strains may be someday.

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    • Jeff, I see you posted here a year ago that you tried CBD and didn't find it that helpful. I'm wondering how long you tried it? Did it ever increase your tacro levels? Thank you

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      • I tried it for a number of months off/on.  I went off for 6 weeks to clear my system as I was also being looked at for a Heart TX.  

        I have to admit my pain is chronic nerve pain - mostly post Shingles which I got in 2016 after my TX team added Myfortic fpr "safety".  3 weeks later Shingles and my pain never left.  I was not told it impacted my Tacro levels as they have been pretty regulated.

        Unrelated, but I would remind all to really make sure you hit the 11.5 Hour mark with your Tacro blood tests.  It is not always mentioned but I keep within 30 minutes of that time by taking night meds based on when I can give blood.  But I cannot speak to level changes. CBD/THC or the like need to be eaten since we cannot smoke anything.  You will find in research how different it may be with where something you eat is metabolized vs something inhaled.

        Last - when I did try either I really only noticed a bit of a body buzz but with all my meds I can/could not regulate when it "kicked in".  2-8 hours sometimes for me. 

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  • Hi Hilary, How are you?

    Do you have any updates? How is the cbd oil use? And which brand do you use?

    I purchased CBD Pure, going to try. Have you tried this brand before? I am looking for an organic, non-gmo, pure clean cbd oil. Thought to consult w. you. Thank you.

    • Hi, I didn't end up trying it. There is a case report of someone's Prograf level becoming dangerously high because of CBD, and the liver enzyme it inhibits is involved in the metabolism of many different drugs it turns out. I'd love to try it but it doesn't seem safe. 

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