Had 2nd Pfizer vaccine and got serology results

Hi everyone,

I would like to update you with my resutls and hopefully it will encourage and help you all.

I had my 2nd Pfizer vaccine on the 19th January 2021 and didn’t have any side effects.

I also did a serology test to see if I had developed any antibodies ... results showed: yes, I now have many antibodies and was told by my doctors to still wear a mask and keep social distancing.
I will put my results here so you can see and compare if you have the same.

I do have some reservations regarding the antibodies though because pre-transplant, I had to have several courses of MAMTERA IV, which neutralises the antibodies in order to prevent organ rejection. Is this not a contradiction then? Does anyone have any idea?

I wish you all well and keep safe.

DEW.

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Replies

  • Congratulations! I am happy for you and stay safe.

  • My transplant team had a webinar recenty and explained that the antibodies are just one factor of the vaccine.  The T-cell response is another indicator. They suggested that we do not become alarmed at the article about antibodies.

    I do know that when I asked a couple of years ago about the Shingles vaccine (Shringrex) that I was told then that I may not have as much protection as another non-transplant patient, but that was not a known fact, but a supposition.

    I think it will be awhile before we know for sure what our level of protection is, but whatever it is it is better than not getting the vaccine.  I don't anticipate getting rid of my mask anytime soon.

    • Thank you very much for posting this.  I also do not anticipate getting rid of my mask any time soon, but I would like to have some idea of how much protection these vaccines provide.  I understand that this information might not be known until after studies are done on tx patients who've had the second dose.

      If we are not to be alarmed at this this article about antibodies, or lack thereof, what are we supposed to make of it?  What DO we know, do you know?  lol

  • How well do COVID vaccines protect after organ transplant? (apnews....

    How well do COVID vaccines protect after organ transplant?
    A new study raised questions about how well COVID-19 vaccines protect organ transplant recipients — and what precautions people with suppressed immun…
    • Two recent (released in the past week) Israeli studies from one of their HMO's report that the Pfizer vaccine is effective for the immunosuppressed (broadly defined - no breakdown), albeit effectiveness is reduced somewhat relative to the non-immunosuppressed.  

      The first report (no citation given) claimed that unvaccinated immunosuppressed patients in their population tested positive for covid-19 at a rate of 3% versus 0.3% for fully vaccinated immunosuppressed patients and versus 0.1% for fully vaccinated, otherwise-healthy patients.

      The second report (https://www.medrxiv.org/content/10.1101/2021.03.16.21253686v1.full) showed significant effectiveness for patients with a variety of comorbidities, including immunosuppression, albeit reduced relative to otherwise-healthy patients.

      No serology information in these studies, but some encouraging real-world results.

      Associations of the BNT162b2 COVID-19 vaccine effectiveness with patient age and comorbidities
      Vaccinations are considered the major tool to curb the current SARS-CoV-2 pandemic. A randomized placebo-controlled trial of the BNT162b2 vaccine has…
      • Well, the problem is the nature of the immunosuppression.  The Johns Hopkins study indicated that if a patient is taking an antimetabolic immunosuppressant, their chances of being protected at all are slim (although this is only after the first dose).  Being immunosuppressed because of, say, cancer treatments is different from being immunosuppressed because of having a solid organ transplant.  I don't think mycophenolic acid is used in cancer treatments.  I do not see mention of this drug in the Israeli study, but it's certainly possible that I just missed it.

    • Gotta say, these study results are extremely disappointing.  Any amont of protection is better than none but I was really hoping the numbers would be more significant that what's stated.  Hopefully after the second dose, the studies will show more favourable numbers.  

      • I know.  I feel gutted but also hope the second dose will prove to be more effective.  I now wonder what the response will be from tx clinics.  Will they recommend not taking this particular class of immunosuppressant for a period before and/or after you get the shot(s)?  Surely they'd have to do a long study about THAT.  The risk of rejection is not something to faff about with.

  •  Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine...

     

    The results of this study don't look so great, so do you mind if I ask you your age and also if you are taking myfortic/mycophenolic acid or any other antimetabolic immunosuppressants?  (This is after only the first shot, it must be said.)  Thanks so much!

     

    Immunogenicity of a Single Dose of SARS-CoV-2 mRNA Vaccine in Solid Organ Transplant Recipients
    This study quantifies antispike protein antibody responses to first-dose messenger RNA (mRNA) COVID-19 vaccines in solid organ transplant recipients…
    • Hi Moosemom,

      Yes I am ove 60 years old and this is actualy my second TP. 
      I take Prograff 2 mg BD prednison 5 mg daily , folic acid daily , blood presure tablets daily , Magnox and Myfortic once daily.

      I was invited by my huspital to take part in research  to find out the amount of antibodies  and  it will be in 5 stages.

       Today was my second blood test. 
      I hope it will be good and will update you when I get the results.

      Take care.

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