Need help with Prograf level

Hello Friends, 

I am struggling with maintaining prograf level since 6 months now and doing weekly blood work to make sure it is in correct level.   

Can you please suggest me how much mg twice a say should I take to maintian level between 5-7 ng/ml ?  Please see below for daily dosage and prograf level after 1 week blood test. 

  •  2 mg twice a day -->  Prograf level less than 2 ng/ml 
  •  3 mg twice a day -->  Prograf level less than 2 ng/ml 
  • 5 mg twice a day --> Prograf level was 9 ng/ml 
  • 4 mg twice a day --> Prograf level was 14 ng/ml

Even doctors cannt suggest anything now.  Next week I will start to try some .5 mg dosages. 


You need to be a member of to add comments!


Email me when people reply –


  • My transplant doctors said that consistency is important. They said I could choose to eat or fast the day I have my blood drawn, but always do it the same way.  I take my Prograf at 8:45 PM, eat a bowl of cereal at 8:00 AM the next morning, and try to arrange to have my blood taken as close to 8:45 AM as I can.  I eat the same kind of cereal the mornings I have my blood draws. I am to avoid eating grapefruit, pomegranate, Seville oranges, and green tea. Black tea is acceptable. I don't take any supplements that have not been approved by my transplant pharmacist. So far, I haven't had a lot of variation in my levels unless there has been a dosage change. I'm sure this has been frustrating for you. Good luck.

  • I'd suggest being careful about adding supplements or foods that you haven't told your docs about.  My prograf level was at 17 at a recent 3-month check and the only thing I could think that I might have done differently was that I had used CBD oil on my painful fingers a few times a week.  So document anything new and let your doctors know.

  • Consistent hydration.

    Avoid grapefruit and also pomegranate products.  

    Your TX team are the ones to adjust your dosage levels.

    • Thanks Antoinetta. 

  • The level is affected by many factors. 

    1. Water intakes, make sure be consistent (for examples 8 glasses of water a day, or so)

    2. The time when you take the med

    3. Tea (for some people)

    4. Definitely no grapefruits


    Goid luck. 

    • Yes I need to quit tea now and lets see how it goes.  Thanks for the suggestion. 

This reply was deleted.

Facebook & instagram

TransplantBuddies & Friends Facebook Group

TransplantBuddies & Friends

Transplant Stories

Members Stories



Lung Transplant Foundation


        Organ Donation Surprising Facts

Latest Activity

oren jeansonne posted a discussion
10 hours ago
oren jeansonne posted a discussion via Latest Activity on
10 hours ago
sumit kapoor and Aarushi are now friends
19 hours ago
sumit kapoor and Aarushi are now friends via Latest Activity on
19 hours ago

Planetary Biosciences for Cystic Fibrosis

Please Donate for CF Patients