My husband is almost 6 years post kidney transplant. His urine creatinine/protein ratio has been creeping up ever since even though his creatinine is good. For example, a year ago his urine creatinine/protein ratio was 1000, six months ago it was 2000 and now it is 4500. His creatinine is still 1.1. Has anyone else experienced this? He will be completing a 24-hour urine and the doctor said he may need a biopsy depending on whether or not the protein is better. He also started him on lisinopril. I'm not really sure if that is supposed to lower it or not. Any thoughts?