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Second Acute Rejection in 2 Months

Hi All, am new to Transplant Friends - got a liver transplant in mid-November 2016.  Had HCC and consider myself quite fortunate that the tumors stayed within the Milan criteria as I was waiting for a donor.  Very grateful to the donor and to all the doctors/reserarchers that make this surgery happen.  Anyway, post transplant I developed what the doctors believe was an acute cellular rejection ('ACR") about 10 days after surgery. (They did not do a biopsy, but went by the increase in liver functions via blood tests.)  Spent two more nights in hospital as they gave me three IVs of methylprednisolone.  That was not difficult compared to the surgery recuperation and the liver function results went down.  About a month later the blood test results started to rise again and right back in hospital for a repeat IV (doctor called it the "big guns") to treat a repeat ACR.  When I got home it was a bit more difficult with mood swings, dizziness, etc. which resulted from the heavy doses of prednisone.  As the oral dose was decreased began to feel more normal and liver function tests are stable.  I am little concerned about another repeat ACR, as I have read that multiple rejections can lead to a chronic rejection - which would be a problem and I presume would require re-transplantation; which is obviously disconcerting.  Anyone have multiple ACRs out there?  Thanks, MikeyM

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  • While kidney and liver Tx are different, I had a few acute rejection episodes with my first Tx. These were throughout the life of the Tx organ (cadaver - 13 years.)  We have little control over these events.   All one can do is follow direction from the Tx team, reporting any changes and leave the rest to them.  

    About worry, since you are not likely to self medicate nor perform your own surgery, worry and stress are a great waste of energy and time, very detrimental to your health.  You do not want live through the good days in fear of things going bad...they will, hopefully not for many, many years. You are alive, stable, and able to enjoy life...better days are ahead, best to enjoy them as they appear.  Stay Well.

  • hi. I hope your rejection settles down. I had my first rejection right after transplant. Doctor put me on IV steroid 3 days then everything was going to normal. Recently doctor reduced prednislone oral dose and on my next blood test my ast alt went a bit up from 33 to 60. Doctor then increased cellcept to 750 and now waiting for next blood test to see if it comes down. May be you reduced some dose?
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