Sudden drop in Tacro level..thoughts?

Hi Everyone  I hope all of you are doing well.  I am 5 years post kidney tx.  My Tacro has consistently come back 5-6.  I had a trough today, and it dropped to 3.2!  I have not missed any doses,  I have not taken any new medications.  I know Tacro can change; however, I'm wondering what might have happened.  My stress level was higher, since I was getting the EvuSheld vaccines for COVID prevention that morning also.  My father was recently diagnosed with cancer, and my daughter is also experiencing some health issues.  Does stress and increased metabolism affect the level?  If so, how? The only other change is that I tried taking in 8 glasses of H2O/day instead of my usual 6.  Now I'm thinking I may have diluted it if that is possible.  I will get a redraw, but I was just wondering if anyone has any thoughts on this.  It aseems a big change suddenly.  Lab error also crossed my mind.  Thanks everyone for any comments.  God Bless all.

You need to be a member of TransplantFriends.com to add comments!

Join TransplantFriends.com

Email me when people reply –

Replies

  • What a coincidence with so many people reporting similar issue! I too had TAC levels drop from 5-6 to 2.54. The dose was increased and now it is back to 5.5. Maybe it was Covid booster dose that upset the balance. I only hope it has not damaged the graft.

  • Hello  Chris, 

    I had same issue in 2018-19 - Low Tacro level and higher Createtine level. Me and my doctor worked hard to back to desrired level but no luck.  What I felt that time was due to my physical activity as I joined Crossfit that time.   After trying for 1 year, my doctor switched me to Belatacept.  

    I think it just happened without any reason atleast for me.   Check with your doc regarding Belatacept,  my createtine is back to normal and no stress to maintain tacro level. 

    Please keep us posted :) Good luck. 

    Thanks. 

     

  • This is so interesting, I logged in to communicate to all what my sister's Nephrologist told her at her appointment today, and I find this coincidence which may not be one at all. My sister appt went well with the exception that her Tacro level was very low howevering aroung 3.0 when it has always been over 6. My Tacro also went down to 4.8 on my last blood work when it has always been above 6 as well. Now, you mentioned this, and I am sure this has to do with the vaccines. In addition, my sister's physician told her to not get another COVID-19 vaccine because they were seeing organ rejection and he has patients hospitalized because of this. I work in healthcare and have a friend who works with Cancer patients, she told me that they have seen an increased of cancer returning in patients that have been in remission from lymphoma. I will not be getting another COVID-19 vaccine.

  • Hi Chris,

    All of the issues you mentioned usually would raise your Creatinine, with the exception of the added water intake. Consider what else has changed, for a moment. Did you have labs drawn at a different time? Maintaining draws at 12 hrs. from your last dose will ensure accurate results.

    It most likely is an aberration. You may be correct that the lab was in error. The best course is to retest before making any other changes. Good Luck! 

    • Thank you for your input.  Labs were due at 9.  They only had one phlebotomist, so it was drawn at 9:15.  Only 15 minutes ate,  but still.  Whenever I tell them it is a timed trough, they always say "you have an hour".  I disagree.  But I'm not sure 15 min would cause such a drop.  Waiting to hear today from transplant center.  I'm sure we will start with a redraw.  Have a happy, healthy day!

This reply was deleted.

Facebook & instagram

TransplantBuddies & Friends Facebook Group

TransplantBuddies & Friends

Transplant Stories

Members Stories

Twitter

COTA

Lung Transplant Foundation

Cystic Fibrosis.com

        Organ Donation Surprising Facts

Latest Activity

Vatsala Srivastava replied to Chris's discussion Sudden drop in Tacro level..thoughts?
9 hours ago
Vatsala Srivastava replied to Chris's discussion Sudden drop in Tacro level..thoughts? via Latest Activity on TransplantFriends.com
9 hours ago
Chris Roman is now a member of TransplantFriends.com
16 hours ago
Chris Roman is now a member of TransplantFriends.com via Latest Activity on TransplantFriends.com
16 hours ago
More…

Planetary Biosciences for Cystic Fibrosis

Please Donate for CF Patients