Hi Everyone I hope all of you are doing well. I am 5 years post kidney tx. My Tacro has consistently come back 5-6. I had a trough today, and it dropped to 3.2! I have not missed any doses, I have not taken any new medications. I know Tacro can change; however, I'm wondering what might have happened. My stress level was higher, since I was getting the EvuSheld vaccines for COVID prevention that morning also. My father was recently diagnosed with cancer, and my daughter is also experiencing some health issues. Does stress and increased metabolism affect the level? If so, how? The only other change is that I tried taking in 8 glasses of H2O/day instead of my usual 6. Now I'm thinking I may have diluted it if that is possible. I will get a redraw, but I was just wondering if anyone has any thoughts on this. It aseems a big change suddenly. Lab error also crossed my mind. Thanks everyone for any comments. God Bless all.