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Hello Friends, 

I had my transplant in OCT 2012.  Everything was good til last 2 quarterly blood work. 

Somehow TACROLIMUS LEVEL going down <2.0 ng/mL  And Creatinine going up 1.27 mg/dL.  Any idea why this is happening ? is this early sign of rejection ? 



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  • Creatinine  1.27 is not bad.  what is your usual creat level?

    My friends creat level is always 1.3 for the past many years

    swelling and urine protein are main symptoms of rejection


    • It is always less than 1 .... I will do one more  test on Friday after increasing prograf dosage .... lets see how it goes ..

  • This may be more related to absorption, than dosage. I am interested in any instructions your team gave you, particularly if the tacrolimus was to be taken with or without food. Please inform us when this issue has been remedied.

  • My doctors increased prograf dose from 2 mg/day to 4 mg/day  ..they will test again next week to see prograf level. 

  • Could only guess.  Did you get your Tac done at 11.5 or 12 hour post dose?

    My creatinine fluctuates a fair amount, usually a tad higher than yours.  Ask the team, see how they interpret the data.

    • Yes it was around 12 hour of gap. I just had test again and waiting for results. I will keep you updated. 

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