Ok: mycophenolic acid and Tacrolimus help each other metabolize in your body, so for each of us we must find the sweet spot between the two. The ratio from one to the other should always be the same once the sweet spot is found. In other words if you must change the dosage on one you must on the other as well. So if you raise one you must the other as well. If you lower one the same applies. What may change is the prednisone ratio against those two. I will post the more I find out what works for me. Please talk to your doctor if possible before changing anything.